It just depends on the finish you like your skin to have. While Strobe Cream is a medium-hydrating (does that make sense?) moisturizer, it does have the pink opalescence to it, giving a very glowy metallic finish on the skin. It can be worn alone or under makeup, but it will definitely influence the finish of the foundation. Example being if you put Studio Fix Fluid over Strobe, it will mattefy it somewhat, but you will still have a fairly glowy result.If that is what you want, then go for it. However if you get very oily throughout the day, this may be too moisturizing and may become "greasy" and may move alot even when set with powders throughout the day.