Karen reminds me almost 100% of my aunt- which can be a good and a bad thing.
My favorite lines from her (there are many):
"You say potato, I say vodka."
"Oh kids ruin everything. I mean look at the stitching on this. You cannot trust a ten year old to do a good hidden button."
"Why did I agree to cook for Stan? I must have been sober. That won't happen again. "
"OK, rule number one. Unless you're served in a frosted glass, never come within four feet of my lips."
"Swell party. My stepson's no longer a virgin. Thanks, Debbie Harry."
(to Jack) "Oh, Honey. You're simple, you're shallow and you're a common whore. That's why we're soul mates."
"They're trying to make gay people straight? Good Lord! Don't they know what that'll do to the fall line? "
"I'm a lady, assface! "