microfine refinisher is your friend!
i have pretty ok skin, but it gets dry and flaky, microfine 3x a week works wonders. gets rid of all skin flakes, then i moisturize, wait about 10 minutes, use a primer if i decide to do so, then use either studio fix fluid, moistureblend, or studio tech. never had a problem yet. at the end of the day, mac wipe to take off makeup, then wash, then moisturize again. i use studio moisture fix on a regular basis, it doesn't make me break out, get oily, get dry, its perfect, and cheaper than a lot of higher end moisturizers. studio moisture cream is slightly heavier than moisutre fix, but i've never actually tried it..i've actually been super impressed with mac skin stuff...