I depot, and have 6 palettes so far (not are all filled) that I arrange by color (blues, greens, neutrals, silvers/blacks, pinks/purple, reds/orange/yellows). I love being able to pull out one thing and see all the colors right there. And I think it makes traveling easier because I can grab just one or two colors groups, and I think they take up less room than all the pots would in luggage.
I go as far as depotting the pre made quads that I have. I just have a thing for everything being in one spot. I figured out I was neglecting the quads because they weren't in the main palettes.
As for depotting, just go slow and be careful. I've never broken/cracked one yet, even after sending a pan flying across the kitchen.